Identifying Structures

In NMR spectroscopy, in addition to the classical metabolites from clinical chemistry such as glucose and cholesterol, numerous other measurands like amino acids, medications, and many other substances are detected. The number of identified substances in the libraries is constantly growing. Compared to other measurement methods, the quantification of defined metabolites is relatively simple, as a universal standard is sufficient and specific standards are not required for all metabolites.

Furthermore, NMR spectroscopy is a useful method in the field of metabolomics, as it not only captures individual substances but can also detect metabolic signatures composed of many substances and spectra. These metabolic signatures contribute to better metabolic characterization of individuals and patients. This allows early detection of health risks in certain groups of people, enabling us to describe and thus diagnose subclinical diseases that have previously remained undetected.

The “NMR Spectroscopy” section aims to address the following topics to facilitate good translation of this technology into laboratory medicine:

• Strengthening collaboration between centers using this technology
• Standardization of measurement protocols to achieve the best possible comparability between platforms
• Dialogue on evaluation methods for NMR spectra
• Establishment of spectral databases
• Development of proficiency tests to document the quality of examinations
• Development of signatures that enable the detection of subclinical diseases (Deep phenotyping; a characterization of individuals based on metabolic changes measured by NMR spectroscopy)
• Close collaboration with other sections within the DGKL to leverage synergies